9mak: Difference between revisions
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==Cryo-EM structure of heteromeric Kir4.1/5.1 potassium channel in complex with Ehop-016== | |||
<StructureSection load='9mak' size='340' side='right'caption='[[9mak]], [[Resolution|resolution]] 3.37Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9mak]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MAK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.37Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EM5:~{N}4-(9-ethylcarbazol-3-yl)-~{N}2-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine'>A1EM5</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mak OCA], [https://pdbe.org/9mak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mak RCSB], [https://www.ebi.ac.uk/pdbsum/9mak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mak ProSAT]</span></td></tr> | ||
[[Category: Ning | </table> | ||
[[Category: | == Disease == | ||
[https://www.uniprot.org/uniprot/KCJ16_HUMAN KCJ16_HUMAN] The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KCJ16_HUMAN KCJ16_HUMAN] Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201).<ref>PMID:24561201</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ge J]] | |||
[[Category: Ning Y]] | |||
[[Category: Yu J]] | |||
Latest revision as of 04:35, 24 June 2026
Cryo-EM structure of heteromeric Kir4.1/5.1 potassium channel in complex with Ehop-016
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