9w8w: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9w8w is ~~ON HOLD until Paper Publication~~

==Structure of backtracked yeast Pol II in complex with a cisplatin-induced inter-strand crosslink lesion at the +2 position.==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9w8w]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W8W OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9W8W FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.91Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9w8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w8w OCA], [https://pdbe.org/9w8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w8w RCSB], [https://www.ebi.ac.uk/pdbsum/9w8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w8w ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/RPB3_YEAST RPB3_YEAST] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Saccharomyces cerevisiae S288C]]

[[Category: Synthetic construct]]

[[Category: Xu J]]

[[Category: Zhu L]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9w8w is ON HOLD  until Paper Publication
+==Structure of backtracked yeast Pol II in complex with a cisplatin-induced inter-strand crosslink lesion at the +2 position.==
+<StructureSection load='9w8w' size='340' side='right'caption='[[9w8w]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9w8w]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W8W FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w8w OCA], [https://pdbe.org/9w8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w8w RCSB], [https://www.ebi.ac.uk/pdbsum/9w8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w8w ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RPB3_YEAST RPB3_YEAST] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Saccharomyces cerevisiae S288C]]
+[[Category: Synthetic construct]]
+[[Category: Xu J]]
+[[Category: Zhu L]]