Monocarboxylate Transporter: Difference between revisions
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m Jaime Prilusky moved page Human Monocarboxylate Transporter 10 (MCT10) to Monocarboxylate Transporter: requested by Editor |
Michal Harel (talk | contribs) No edit summary |
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== Mechanism of Action == | == Mechanism of Action == | ||
MCT10 likely operates via a '''"rocker-switch" mechanism'''. Comparison with AlphaFold models suggests that the N- and C-terminal bundles move as rigid bodies to alternatingly expose the binding site. A distinct kink in '''TM1''' (residues Gln88 and Asn89) acts as a sensor, likely triggering the conformational switch upon substrate binding. | MCT10 likely operates via a '''"rocker-switch" mechanism'''. Comparison with AlphaFold models suggests that the N- and C-terminal bundles move as rigid bodies to alternatingly expose the binding site. A distinct kink in '''TM1''' (residues Gln88 and Asn89) acts as a sensor, likely triggering the conformational switch upon substrate binding. | ||
== 3D sructures of monocarboxylate transporter == | |||
[[Monocarboxylate transporter 3D structures]] | |||
== References == | == References == | ||
