NolR: Difference between revisions
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==Structure Tour== | ==Structure Tour== | ||
<StructureSection load='4omz' size='350' side='right' caption='Crystal Structure of NolR from | <StructureSection load='4omz' size='350' side='right' caption='Crystal Structure of NolR from Sinorhizobium fredii complex with phosphate (PDB entry [[4omz]])' scene=''> | ||
===Abstract=== | ===Abstract=== | ||
The symbiosis between rhizobial bacteria and leguminous plants is a critical ecological process leading to nitrogen fixation. This process is tightly regulated by a series of ''nod'' genes. '''NolR''' is a global regulatory protein (transcription factor) conserved across ''Sinorhizobium'' and ''Rhizobium'' species that represses these nodulation genes to optimize symbiosis. This paper presents the crystal structures of NolR in both unliganded and DNA-bound forms, revealing an asymmetric binding mechanism and a specific conformational switch that allows the protein to recognize variable DNA sequences. | The symbiosis between rhizobial bacteria and leguminous plants is a critical ecological process leading to nitrogen fixation. This process is tightly regulated by a series of ''nod'' genes. '''NolR''' is a global regulatory protein (transcription factor) conserved across ''Sinorhizobium'' and ''Rhizobium'' species that represses these nodulation genes to optimize symbiosis. This paper presents the crystal structures of NolR in both unliganded and DNA-bound forms, revealing an asymmetric binding mechanism and a specific conformational switch that allows the protein to recognize variable DNA sequences. | ||
