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'''Unreleased structure'''


The entry 23sr is ON HOLD  until Paper Publication
==Cryo-EM structure of CDK2 in complex with CRBN/DDB1 and B11==
 
<StructureSection load='23sr' size='340' side='right'caption='[[23sr]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
Authors: Li, X.Z., Jiang, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[23sr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=23SR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=23SR FirstGlance]. <br>
Description: Cryo-EM structure of CDK2 in complex with CRBN/DDB1 and B11
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1E59:spiro[3.3]heptan-2-ylmethyl+~{N}-[[3-[(3~{R})-2,6-bis(oxidanylidene)piperidin-3-yl]-8-chloranyl-6-fluoranyl-4-oxidanylidene-quinazolin-7-yl]methyl]carbamate'>A1E59</scene></td></tr>
[[Category: Li, X.Z]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=23sr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=23sr OCA], [https://pdbe.org/23sr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=23sr RCSB], [https://www.ebi.ac.uk/pdbsum/23sr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=23sr ProSAT]</span></td></tr>
[[Category: Jiang, Y]]
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Autosomal recessive nonsyndromic intellectual deficit;Distal monosomy 3p. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.<ref>PMID:18414909</ref> <ref>PMID:20223979</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Jiang Y]]
[[Category: Li XZ]]
Retrieved from "https://proteopedia.org/23sr"