7s1g: Difference between revisions

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</table>

== Function ==

[https://www.uniprot.org/uniprot/~~RL23_ECOLI RL23_ECOLI~~] ~~One of~~ the ~~early assembly proteins,~~ it ~~binds~~ 23S rRNA~~; is essential for growth. One~~ of the ~~proteins that surround the polypeptide exit tunnel on the outside~~ of the ~~subunit~~. ~~Acts as the docking~~ site ~~for trigger factor~~ (PubMed:~~12226666~~) ~~for Ffh binding to~~ the ribosome (~~SRP54, PubMed:12756233 and~~ PubMed:~~12702815~~) and to ~~nascent polypeptide chains (PubMed~~:~~12756233)~~.[HAMAP-Rule:~~MF_01369~~]

[https://www.uniprot.org/uniprot/RS19_ECOLI RS19_ECOLI] In the E.coli 70S ribosome in the initiation state (PubMed:12809609) it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B1a; this bridge is broken in the model with bound EF-G. The 23S rRNA contact site in bridge B1a is modeled to differ in different ribosomal states (PubMed:12859903), contacting alternately S13 or S19. In the 3.5 angstroms resolved ribosome structures (PubMed:16272117) the contacts between L5, S13 and S19 bridge B1b are different, confirming the dynamic nature of this interaction. Bridge B1a is not visible in the crystallized ribosomes due to 23S rRNA disorder.[HAMAP-Rule:MF_00531] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. Contacts the A site tRNA.[HAMAP-Rule:MF_00531]

== Publication Abstract from PubMed ==

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 </table>
 == Function ==
-[https://www.uniprot.org/uniprot/RL23_ECOLI RL23_ECOLI] One of the early assembly proteins, it binds 23S rRNA; is essential for growth. One of the proteins that surround the polypeptide exit tunnel on the outside of the subunit. Acts as the docking site for trigger factor (PubMed:12226666) for Ffh binding to the ribosome (SRP54, PubMed:12756233 and PubMed:12702815) and to nascent polypeptide chains (PubMed:12756233).[HAMAP-Rule:MF_01369]
+[https://www.uniprot.org/uniprot/RS19_ECOLI RS19_ECOLI] In the E.coli 70S ribosome in the initiation state (PubMed:12809609) it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B1a; this bridge is broken in the model with bound EF-G. The 23S rRNA contact site in bridge B1a is modeled to differ in different ribosomal states (PubMed:12859903), contacting alternately S13 or S19. In the 3.5 angstroms resolved ribosome structures (PubMed:16272117) the contacts between L5, S13 and S19 bridge B1b are different, confirming the dynamic nature of this interaction. Bridge B1a is not visible in the crystallized ribosomes due to 23S rRNA disorder.[HAMAP-Rule:MF_00531]  Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. Contacts the A site tRNA.[HAMAP-Rule:MF_00531]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==