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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y8p OCA], [https://pdbe.org/7y8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y8p RCSB], [https://www.ebi.ac.uk/pdbsum/7y8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y8p ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y8p OCA], [https://pdbe.org/7y8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y8p RCSB], [https://www.ebi.ac.uk/pdbsum/7y8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y8p ProSAT]</span></td></tr> |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
| |
| == Publication Abstract from PubMed ==
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| A large number of chemically modified oligonucleotides (ONs) have been developed for RNA-based technologies. In most modified RNAs, the characteristic 2'-hydroxyl (2'-OH) groups are removed to enhance both nuclease resistance and hybridization ability. However, the importance of the 2'-OH group in RNA structure and function is well known. Here, we report the synthesis and properties of 4'-selenoRNA in which all four nucleoside units retain the 2'-OH groups but contain a selenium atom instead of an oxygen atom at the 4'-position of the furanose ring. 4'-SelenoRNA has enhanced ability to form duplexes with RNA, and high endonuclease resistance despite the presence of the 2'-OH groups. X-ray crystallography analysis showed that the 4'-selenoRNA duplex adopts an A-conformation, similar to natural RNA, although one 4'-selenocytidine residue has unusual South-type sugar puckering. Furthermore, preliminary studies using 4'-seleno-modified siRNAs suggest that 4'-selenoRNA may be applicable to RNA interference technology. Collectively, our results raise the possibility of a new class of modified RNA in which 2'-OH groups do not need to be masked.
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| Synthesis and properties of fully-modified 4'-selenoRNA, an endonuclease-resistant RNA analog.,Ota M, Takahashi H, Nogi Y, Kagotani Y, Saito-Tarashima N, Kondo J, Minakawa N Bioorg Med Chem. 2022 Dec 15;76:117093. doi: 10.1016/j.bmc.2022.117093. Epub 2022 , Nov 19. PMID:36434923<ref>PMID:36434923</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 7y8p" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
