9q3e: Difference between revisions

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'''Unreleased structure'''


The entry 9q3e is ON HOLD  until Paper Publication
==Cryo-EM structure of RotavirusA NSP1-ELOB-ELOC-CUL3==
 
<StructureSection load='9q3e' size='340' side='right'caption='[[9q3e]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9q3e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rotavirus_A Rotavirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Q3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Q3E FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9q3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9q3e OCA], [https://pdbe.org/9q3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9q3e RCSB], [https://www.ebi.ac.uk/pdbsum/9q3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9q3e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NSP1_ROTHP NSP1_ROTHP] Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities. Recognizes the host NF-kappa-B regulator BTRC through the presence of a DSGXS motif in the C-terminal substrate recognition domain.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Rotavirus A]]
[[Category: Baek K]]
[[Category: Fischer ES]]
[[Category: Glassman CR]]
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