9rnj: Difference between revisions
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The entry | ==Cryo-EM structure of the human potassium chloride cotransporter T906A/T1007A phospho-knockout mutants KCC2b bound ATP in LMNG (outward-facing state, dimer)== | ||
<StructureSection load='9rnj' size='340' side='right'caption='[[9rnj]], [[Resolution|resolution]] 3.86Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9rnj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RNJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.86Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=JUX:N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide'>JUX</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rnj OCA], [https://pdbe.org/9rnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rnj RCSB], [https://www.ebi.ac.uk/pdbsum/9rnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rnj ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/S12A5_HUMAN S12A5_HUMAN] Malignant migrating focal seizures of infancy. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/S12A5_HUMAN S12A5_HUMAN] Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262).[UniProtKB:Q63633]<ref>PMID:24668262</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Duerr KL]] | |||
[[Category: Jazayeri A]] | |||
[[Category: Matsuoka R]] | |||
[[Category: Oswald C]] | |||
Latest revision as of 07:24, 8 July 2026
Cryo-EM structure of the human potassium chloride cotransporter T906A/T1007A phospho-knockout mutants KCC2b bound ATP in LMNG (outward-facing state, dimer)
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