9whc: Difference between revisions
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==Crystal structure of human nNOS PDZ domain in complex with compound N28== | |||
<StructureSection load='9whc' size='340' side='right'caption='[[9whc]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9whc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WHC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EWG:8-fluoranyl-6-[(2-fluoranyl-4-methyl-phenyl)methyl]-1,2$l^{6},3-benzoxathiazine+2,2-dioxide'>A1EWG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9whc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9whc OCA], [https://pdbe.org/9whc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9whc RCSB], [https://www.ebi.ac.uk/pdbsum/9whc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9whc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NOS1_HUMAN NOS1_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Yang S]] | |||
[[Category: Zhang L]] | |||
Latest revision as of 07:32, 8 July 2026
Crystal structure of human nNOS PDZ domain in complex with compound N28
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