User:Angel Herraez/Sandbox 14: Difference between revisions
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<!-- Structure load='3kg2' size='500' scene='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Default3kg2/1' caption='The rat glycosylated glutamate receptor in complex with a competitive antagonist ([[3kg2]])' name='main1STwindow' / --> | <!-- | ||
<Structure load='3kg2' size='500' scene='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Default3kg2/1' caption='The rat glycosylated glutamate receptor in complex with a competitive antagonist ([[3kg2]])' name='main1STwindow' /> | |||
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<name>main1STwindow</name> | |||
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<script> script /wiki/scripts/User:Wayne_Decatur/Sandbox_Glutamate_receptor/Default3kg2/1.spt </script> | |||
<caption>The rat glycosylated glutamate receptor in complex with a competitive antagonist ([[3kg2]]) </caption> | |||
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===Subunit Non-Equivalence, Transmembrane Domain Architecture and the Occluded Pore=== | ===Subunit Non-Equivalence, Transmembrane Domain Architecture and the Occluded Pore=== | ||
< | <div style="float:left;"> | ||
< | <!-- <Structure load='3kg2' size='500' scene ='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Default3kg2/1' caption='Glutamate Receptor Structure (PDB code [[3kg2]])' name='main2NDwindow' /> | ||
< | --> | ||
<table cellpadding='2' style='width: | <jmol> | ||
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<script> script /wiki/scripts/User:Wayne_Decatur/Sandbox_Glutamate_receptor/Default3kg2/1.spt </script> | |||
<caption>Glutamate Receptor Structure (PDB code [[3kg2]]) </caption> | |||
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<table cellpadding='2' style='width:400px;'> | |||
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<td style='vertical-align:top; background-color:#eeeeee'><applet load='3kg2' size='190' frame='true' scene='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Ac3kg2letter/1' caption='A is equivalent to C'/> | <td style='vertical-align:top; background-color:#eeeeee; padding:15px;'> | ||
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<applet load='3kg2' size='190' frame='true' scene='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Ac3kg2letter/1' caption='A is equivalent to C'/> | |||
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<script> script /wiki/scripts/User:Wayne_Decatur/Sandbox_Glutamate_receptor/Ac3kg2letter/1.spt </script> | |||
<caption>A is equivalent to C </caption> | |||
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</jmol> | |||
</td> | </td> | ||
<td style='vertical-align:top; background-color:#eeeeee><applet load='3kg2' size='190' frame='true' scene='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Bd3kg2letter/2' caption='B is equivalent to D'/> | <td style='vertical-align:top; background-color:#eeeeee; padding:15px;'> | ||
<!-- | |||
<applet load='3kg2' size='190' frame='true' scene='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Bd3kg2letter/2' caption='B is equivalent to D'/> | |||
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<name>showBD</name> | |||
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<frame>true</frame> | |||
<script> script /wiki/scripts/User:Wayne_Decatur/Sandbox_Glutamate_receptor/Bd3kg2letter/2.spt </script> | |||
<caption>B is equivalent to D </caption> | |||
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</ | |||
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===Subunit non-equivalence=== | ===Subunit non-equivalence=== | ||
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*The TMD domain of the GluA2 receptor shares structural and sequence similarity with the pore region of the potassium (K+), as hinted at by earlier work<ref name ="pot1">PMID: 7539962</ref><ref name ="pot2">PMID: 7761417</ref><ref name ="pot3">PMID: 9525859</ref>. Here the pore region of ''Streptomyces lividans'' potassium channel ([[1bl8]])<scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Gluvspottmd/4' target='main2NDwindow'> superposed with the TMD domain of GluA2</scene>, specifically the <scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Gluvspottmdm3/1' target='main2NDwindow'>inner helix of the K+ channel aligned with the M3 segment</scene>. The <scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Gluvspottmdm1/2' target='main2NDwindow'>M1 segment of GluA2 also overlays well with the outer helix</scene> of the K+ channel even though these portions weren't even included in the calculation of the alignment seen here. | *The TMD domain of the GluA2 receptor shares structural and sequence similarity with the pore region of the potassium (K+), as hinted at by earlier work<ref name ="pot1">PMID: 7539962</ref><ref name ="pot2">PMID: 7761417</ref><ref name ="pot3">PMID: 9525859</ref>. Here the pore region of ''Streptomyces lividans'' potassium channel ([[1bl8]])<scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Gluvspottmd/4' target='main2NDwindow'> superposed with the TMD domain of GluA2</scene>, specifically the <scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Gluvspottmdm3/1' target='main2NDwindow'>inner helix of the K+ channel aligned with the M3 segment</scene>. The <scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Gluvspottmdm1/2' target='main2NDwindow'>M1 segment of GluA2 also overlays well with the outer helix</scene> of the K+ channel even though these portions weren't even included in the calculation of the alignment seen here. | ||
==Details of Structure Featured== | ==Details of Structure Featured== | ||
