1ycj: Difference between revisions
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'''Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate''' | '''Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate''' | ||
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[[Category: Skov, L K.]] | [[Category: Skov, L K.]] | ||
[[Category: Vestergaard, B.]] | [[Category: Vestergaard, B.]] | ||
[[Category: | [[Category: Glur5 ligand-binding core]] | ||
[[Category: | [[Category: Ionotropic glutamate receptor]] | ||
[[Category: | [[Category: Kainate receptor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:09:15 2008'' | |||
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Revision as of 13:09, 3 May 2008
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
Overview
The X-ray structure of the ligand-binding core of the kainate receptor GluR5 (GluR5-S1S2) in complex with (S)-glutamate was determined to 1.95 A resolution. The overall GluR5-S1S2 structure comprises two domains and is similar to the related AMPA receptor GluR2-S1S2J. (S)-glutamate binds as in GluR2-S1S2J. Distinct features are observed for Ser741, which stabilizes a highly coordinated network of water molecules and forms an interdomain bridge. The GluR5 complex exhibits a high degree of domain closure (26 degrees) relative to apo GluR2-S1S2J. In addition, GluR5-S1S2 forms a novel dimer interface with a different arrangement of the two protomers compared to GluR2-S1S2J.
About this Structure
1YCJ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate., Naur P, Vestergaard B, Skov LK, Egebjerg J, Gajhede M, Kastrup JS, FEBS Lett. 2005 Feb 14;579(5):1154-60. PMID:15710405 Page seeded by OCA on Sat May 3 16:09:15 2008
