10mn: Difference between revisions
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==Crystal structure of human OGG1 (WT) in a product bound state in the presence of the agonist F51== | |||
<StructureSection load='10mn' size='340' side='right'caption='[[10mn]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[10mn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10MN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10MN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C6R:1-[(2S)-2-(benzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole'>A1C6R</scene>, <scene name='pdbligand=A1C6S:(2Z)-4-hydroxypenta-2,4-dienal'>A1C6S</scene>, <scene name='pdbligand=A1C6T:(2R,3E)-2-hydroxy-5-oxopent-3-en-1-yl+dihydrogen+phosphate'>A1C6T</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10mn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10mn OCA], [https://pdbe.org/10mn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10mn RCSB], [https://www.ebi.ac.uk/pdbsum/10mn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10mn ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Lloyd | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Arvai AS]] | |||
[[Category: Lloyd RS]] | |||
[[Category: Syed A]] | |||
[[Category: Tainer JA]] | |||
Latest revision as of 06:55, 15 July 2026
Crystal structure of human OGG1 (WT) in a product bound state in the presence of the agonist F51
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