9k91: Difference between revisions
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==Cryo-EM structure of human histone deacetylase 6 tandem catalytic domain (HDAC6 CD1-2)== | |||
<StructureSection load='9k91' size='340' side='right'caption='[[9k91]], [[Resolution|resolution]] 3.86Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9k91]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K91 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.86Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k91 OCA], [https://pdbe.org/9k91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k91 RCSB], [https://www.ebi.ac.uk/pdbsum/9k91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k91 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HDAC6_HUMAN HDAC6_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.<ref>PMID:12024216</ref> <ref>PMID:17846173</ref> In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.<ref>PMID:12024216</ref> <ref>PMID:17846173</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chao Y]] | |||
[[Category: Qu Q]] | |||
[[Category: Sun C]] | |||
[[Category: Xie K]] | |||
[[Category: Zhou Z]] | |||
[[Category: Zhu Y]] | |||
[[Category: Zhu Z]] | |||
Latest revision as of 07:03, 15 July 2026
Cryo-EM structure of human histone deacetylase 6 tandem catalytic domain (HDAC6 CD1-2)
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