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'''Unreleased structure'''


The entry 9rtf is ON HOLD  until Paper Publication
==Crystal structure of the human serum transferrin with Fe(III) bound at the C-lobe only==
 
<StructureSection load='9rtf' size='340' side='right'caption='[[9rtf]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
Authors: Paolillo, M., Ferraro, G., Banneville, A.S., Cornaciu, I., Pica, A., Merlino, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9rtf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RTF FirstGlance]. <br>
Description: Crystal structure of the human serum transferrin with Fe(III) bound at the C-lobe only
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Paolillo, M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rtf OCA], [https://pdbe.org/9rtf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rtf RCSB], [https://www.ebi.ac.uk/pdbsum/9rtf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rtf ProSAT]</span></td></tr>
[[Category: Pica, A]]
</table>
[[Category: Banneville, A.S]]
== Disease ==
[[Category: Ferraro, G]]
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
[[Category: Merlino, A]]
== Function ==
[[Category: Cornaciu, I]]
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Banneville AS]]
[[Category: Cornaciu I]]
[[Category: Ferraro G]]
[[Category: Merlino A]]
[[Category: Paolillo M]]
[[Category: Pica A]]
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