9t5j: Difference between revisions

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'''Unreleased structure'''


The entry 9t5j is ON HOLD  until Paper Publication
==RPAP2-GPN1-GPN3 complex (GDP-bound)==
 
<StructureSection load='9t5j' size='340' side='right'caption='[[9t5j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9t5j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T5J FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t5j OCA], [https://pdbe.org/9t5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t5j RCSB], [https://www.ebi.ac.uk/pdbsum/9t5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t5j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RPAP2_HUMAN RPAP2_HUMAN] Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681).<ref>PMID:17643375</ref> <ref>PMID:22137580</ref> <ref>PMID:24997600</ref> <ref>PMID:30118681</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bernecky C]]
[[Category: Hlavata A]]
Retrieved from "https://proteopedia.org/9t5j"