35tl: Difference between revisions
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==PD-L1 complexed with Germinal-designed anti-PD-L1 scFv H5== | |||
<StructureSection load='35tl' size='340' side='right'caption='[[35tl]], [[Resolution|resolution]] 3.93Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[35tl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=35TL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=35TL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.93Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=35tl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=35tl OCA], [https://pdbe.org/35tl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=35tl RCSB], [https://www.ebi.ac.uk/pdbsum/35tl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=35tl ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Feng L]] | |||
[[Category: Rao B]] | |||
[[Category: Zhang JL]] | |||