9mvd: Difference between revisions
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==Dengue virus serotype-3 (DENV3) immature structure at 4C== | |||
<StructureSection load='9mvd' size='340' side='right'caption='[[9mvd]], [[Resolution|resolution]] 6.13Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9mvd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MVD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.13Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mvd OCA], [https://pdbe.org/9mvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mvd RCSB], [https://www.ebi.ac.uk/pdbsum/9mvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mvd ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q6DRA0_DENV3 Q6DRA0_DENV3] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Regulates the ATPase activity of the NS3 helicase activity. NS4A allows NS3 helicase to conserve energy during unwinding. Plays a role in the inhibition of the host innate immune response. Interacts with host MAVS and thereby prevents the interaction between RIGI and MAVS. In turn, IFN-beta production is impaired. Interacts with host AUP1 which mediates induction of lipophagy in host cells and facilitates production of virus progeny particles.[ARBA:ARBA00045521] Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.[ARBA:ARBA00035601] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dengue virus 3]] | |||
[[Category: Large Structures]] | |||
[[Category: Are VN]] | |||
[[Category: Fokine A]] | |||
[[Category: Klose T]] | |||
[[Category: Kuhn RJ]] | |||
Latest revision as of 16:09, 22 July 2026
Dengue virus serotype-3 (DENV3) immature structure at 4C
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