9mve: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9mve is ~~ON HOLD~~ ~~until 2027~~-07-14

==Dengue virus serotype-3 (DENV3) complex with DC-SIGN CRD at 4C==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9mve]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MVE OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9MVE FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9mve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mve OCA], [https://pdbe.org/9mve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mve RCSB], [https://www.ebi.ac.uk/pdbsum/9mve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mve ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/Q6DRA0_DENV3 Q6DRA0_DENV3] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Regulates the ATPase activity of the NS3 helicase activity. NS4A allows NS3 helicase to conserve energy during unwinding. Plays a role in the inhibition of the host innate immune response. Interacts with host MAVS and thereby prevents the interaction between RIGI and MAVS. In turn, IFN-beta production is impaired. Interacts with host AUP1 which mediates induction of lipophagy in host cells and facilitates production of virus progeny particles.[ARBA:ARBA00045521] Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.[ARBA:ARBA00035601]

__TOC__

</StructureSection>

[[Category: Dengue virus 3]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Are VN]]

[[Category: Fokine A]]

[[Category: Klose T]]

[[Category: Kuhn RJ]]

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-'''Unreleased structure'''
-The entry 9mve is ON HOLD  until 2027-07-14
+==Dengue virus serotype-3 (DENV3) complex with DC-SIGN CRD at 4C==
+<StructureSection load='9mve' size='340' side='right'caption='[[9mve]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9mve]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MVE FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mve OCA], [https://pdbe.org/9mve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mve RCSB], [https://www.ebi.ac.uk/pdbsum/9mve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mve ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q6DRA0_DENV3 Q6DRA0_DENV3] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317]  Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504]  Regulates the ATPase activity of the NS3 helicase activity. NS4A allows NS3 helicase to conserve energy during unwinding. Plays a role in the inhibition of the host innate immune response. Interacts with host MAVS and thereby prevents the interaction between RIGI and MAVS. In turn, IFN-beta production is impaired. Interacts with host AUP1 which mediates induction of lipophagy in host cells and facilitates production of virus progeny particles.[ARBA:ARBA00045521]  Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.[ARBA:ARBA00035601]
+__TOC__
+</StructureSection>
+[[Category: Dengue virus 3]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Are VN]]
+[[Category: Fokine A]]
+[[Category: Klose T]]
+[[Category: Kuhn RJ]]