9wzy: Difference between revisions
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==Crystal Structure of BRD4 BD1 Domain Complexed with a Molecular Glue Probe== | |||
<StructureSection load='9wzy' size='340' side='right'caption='[[9wzy]], [[Resolution|resolution]] 2.62Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9wzy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WZY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EYU:4-fluoranyl-3-nitro-benzoic+acid'>A1EYU</scene>, <scene name='pdbligand=EDN:ETHANE-1,2-DIAMINE'>EDN</scene>, <scene name='pdbligand=LPH:L-PROPARGYLGLYCINE'>LPH</scene>, <scene name='pdbligand=WG0:2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoic+acid'>WG0</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wzy OCA], [https://pdbe.org/9wzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wzy RCSB], [https://www.ebi.ac.uk/pdbsum/9wzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wzy ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Cao | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
[[Category: | == Function == | ||
[[Category: Li | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Cao H]] | |||
[[Category: Chang M]] | |||
[[Category: Hu X]] | |||
[[Category: Li W]] | |||
[[Category: Ren Y]] | |||
[[Category: Wan J]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 16:27, 22 July 2026
Crystal Structure of BRD4 BD1 Domain Complexed with a Molecular Glue Probe
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