9s0s: Difference between revisions

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'''Unreleased structure'''


The entry 9s0s is ON HOLD until Paper Publication
==Cryo-EM structure of human NHE6 in C2 symmetry==
 
<StructureSection load='9s0s' size='340' side='right'caption='[[9s0s]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9s0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S0S FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s0s OCA], [https://pdbe.org/9s0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s0s RCSB], [https://www.ebi.ac.uk/pdbsum/9s0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s0s ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SL9A6_HUMAN SL9A6_HUMAN] Christianson syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease may be caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SL9A6_HUMAN SL9A6_HUMAN] Endosomal Na(+), K(+)/H(+) antiporter (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (PubMed:20130086). Regulates intracellular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity).[UniProtKB:A1L3P4]<ref>PMID:15522866</ref> <ref>PMID:20130086</ref> <ref>PMID:28635961</ref> <ref>PMID:31676550</ref> <ref>PMID:32277048</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Autzen HE]]
[[Category: Brauer CM]]
[[Category: Faergeman NJ]]
[[Category: Feilen LP]]
[[Category: Ginsthofer M]]
[[Category: Havelund JF]]
[[Category: Kragelund BB]]
[[Category: Lalic MR]]
[[Category: Ma L]]
[[Category: Morrow EM]]
[[Category: Ostendorf J]]
[[Category: Pedersen SF]]
[[Category: Sach L]]
[[Category: Tranchant EE]]
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