9w2n: Difference between revisions
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==Crystal structure of the mutant LC3B in complex with p62== | |||
<StructureSection load='9w2n' size='340' side='right'caption='[[9w2n]], [[Resolution|resolution]] 1.67Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9w2n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W2N FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[Category: Biswal | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w2n OCA], [https://pdbe.org/9w2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w2n RCSB], [https://www.ebi.ac.uk/pdbsum/9w2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w2n ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Pal | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MLP3B_MOUSE MLP3B_MOUSE] Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.[UniProtKB:Q9GZQ8] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Biswal BK]] | |||
[[Category: Mathur S]] | |||
[[Category: Pal RK]] | |||
[[Category: Thukral L]] | |||
Latest revision as of 20:31, 29 July 2026
Crystal structure of the mutant LC3B in complex with p62
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