9zm5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9zm5 is ~~ON HOLD until Paper Publication~~

==Crystal structure of the Arabidopsis NPR1-NIMIN1 complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9zm5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZM5 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9ZM5 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.33Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900010:alpha-maltotetraose'>PRD_900010</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zm5 OCA], [https://pdbe.org/9zm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zm5 RCSB], [https://www.ebi.ac.uk/pdbsum/9zm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zm5 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/NPR1_ARATH NPR1_ARATH] May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, a biphasic change in cellular reduction potential occurs, resulting in reduction of the cytoplasmic oligomeric form to a monomeric form that accumulates in the nucleus and activates gene expression. Phosphorylated form is target of proteasome degradation.<ref>PMID:11607555</ref> <ref>PMID:12615947</ref> <ref>PMID:12837250</ref> <ref>PMID:12897257</ref> <ref>PMID:12953119</ref> <ref>PMID:9002272</ref> <ref>PMID:9019406</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arabidopsis thaliana]]

[[Category: Escherichia coli]]

[[Category: Large Structures]]

[[Category: Gish ML]]

[[Category: Zhang S]]

[[Category: Zheng N]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9zm5 is ON HOLD  until Paper Publication
+==Crystal structure of the Arabidopsis NPR1-NIMIN1 complex==
+<StructureSection load='9zm5' size='340' side='right'caption='[[9zm5]], [[Resolution|resolution]] 3.33&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9zm5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZM5 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.33&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900010:alpha-maltotetraose'>PRD_900010</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zm5 OCA], [https://pdbe.org/9zm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zm5 RCSB], [https://www.ebi.ac.uk/pdbsum/9zm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zm5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NPR1_ARATH NPR1_ARATH] May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, a biphasic change in cellular reduction potential occurs, resulting in reduction of the cytoplasmic oligomeric form to a monomeric form that accumulates in the nucleus and activates gene expression. Phosphorylated form is target of proteasome degradation.<ref>PMID:11607555</ref> <ref>PMID:12615947</ref> <ref>PMID:12837250</ref> <ref>PMID:12897257</ref> <ref>PMID:12953119</ref> <ref>PMID:9002272</ref> <ref>PMID:9019406</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arabidopsis thaliana]]
+[[Category: Escherichia coli]]
+[[Category: Large Structures]]
+[[Category: Gish ML]]
+[[Category: Zhang S]]
+[[Category: Zheng N]]