9psq: Difference between revisions
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==Co-crystal structure of BAF60A (SMARCD1) bound to PPSC-001== | |||
<StructureSection load='9psq' size='340' side='right'caption='[[9psq]], [[Resolution|resolution]] 2.31Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9psq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PSQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CLC:(4M)-4-(3-bromophenyl)-2-methyl-N-(6-methylpyridin-2-yl)-5-oxo-5,6,7,8-tetrahydroquinoline-3-carboxamide'>A1CLC</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9psq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9psq OCA], [https://pdbe.org/9psq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9psq RCSB], [https://www.ebi.ac.uk/pdbsum/9psq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9psq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SMRD1_HUMAN SMRD1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342).[UniProtKB:Q61466]<ref>PMID:12917342</ref> <ref>PMID:14698202</ref> <ref>PMID:29374058</ref> <ref>PMID:8804307</ref> <ref>PMID:22952240</ref> <ref>PMID:26601204</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bellon SF]] | |||
[[Category: Clasman JC]] | |||
[[Category: Davenport YW]] | |||
[[Category: Nelen M]] | |||
[[Category: Sadalge DS]] | |||
[[Category: Taherbhoy AM]] | |||
[[Category: Von der Porten L]] | |||
Latest revision as of 07:13, 5 August 2026
Co-crystal structure of BAF60A (SMARCD1) bound to PPSC-001
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