9ydi: Difference between revisions
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==Dickerson dodecamer RNA duplex containing an A/G mismatch.== | |||
<StructureSection load='9ydi' size='340' side='right'caption='[[9ydi]], [[Resolution|resolution]] 1.03Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ydi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YDI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.03Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ydi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ydi OCA], [https://pdbe.org/9ydi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ydi RCSB], [https://www.ebi.ac.uk/pdbsum/9ydi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ydi ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We describe a strategy for the synthesis of DNA, RNA and 2'-O-methyl (2'-O-Me) oligonucleotides containing 2-fluoro-adenine (A(F)) and isoguanine (iG) nucleobases. To the best of our knowledge, this is the first nonenzymatic route for the synthesis of oligonucleotides containing 2-fluoro-adenine. We also describe the hydrolytic strategy for the conversion of 2-fluoro-adenine into isoguanine. Unlike 2,6-diaminopurine, 2-fluoro-adenine and isoguanine modifications are thermally destabilizing in the context of DNA, RNA, and 2'-O-methyl oligonucleotide duplexes. | |||
A Postsynthetic Strategy for Oligonucleotides Containing 2-Fluoro-adenine and Isoguanine Nucleobases.,Madaoui M, Kundu J, Datta D, Harp JM, Egli M, Manoharan M Org Lett. 2026 Jul 24;28(29):9133-9138. doi: 10.1021/acs.orglett.6c01203. Epub , 2026 Jul 15. PMID:42455745<ref>PMID:42455745</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 9ydi" style="background-color:#fffaf0;"></div> | ||
[[Category: Egli | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Egli ME]] | |||
[[Category: Harp JM]] | |||
Latest revision as of 07:28, 5 August 2026
Dickerson dodecamer RNA duplex containing an A/G mismatch.
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