9xi4: Difference between revisions

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'''Unreleased structure'''


The entry 9xi4 is ON HOLD  until Paper Publication
==SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with BD56-104 Fab and ACE2==
 
<StructureSection load='9xi4' size='340' side='right'caption='[[9xi4]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
Authors: Niu, C., Liu, B., Gao, X., Li, Z., He, J., Xiong, X.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9xi4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XI4 FirstGlance]. <br>
Description: SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with BD56-104 Fab and ACE2
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Niu, C]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xi4 OCA], [https://pdbe.org/9xi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xi4 RCSB], [https://www.ebi.ac.uk/pdbsum/9xi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xi4 ProSAT]</span></td></tr>
[[Category: Gao, X]]
</table>
[[Category: Liu, B]]
== Function ==
[[Category: Xiong, X]]
[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>
[[Category: He, J]]
== References ==
[[Category: Li, Z]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Severe acute respiratory syndrome coronavirus 2]]
[[Category: Gao X]]
[[Category: He J]]
[[Category: Li Z]]
[[Category: Liu B]]
[[Category: Niu C]]
[[Category: Xiong X]]
Retrieved from "https://proteopedia.org/9xi4"