1gid: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gid OCA], [https://pdbe.org/1gid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gid RCSB], [https://www.ebi.ac.uk/pdbsum/1gid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gid ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gid OCA], [https://pdbe.org/1gid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gid RCSB], [https://www.ebi.ac.uk/pdbsum/1gid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gid ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Group I self-splicing introns catalyze their own excision from precursor RNAs by way of a two-step transesterification reaction. The catalytic core of these ribozymes is formed by two structural domains. The 2.8-angstrom crystal structure of one of these, the P4-P6 domain of the Tetrahymena thermophila intron, is described. In the 160-nucleotide domain, a sharp bend allows stacked helices of the conserved core to pack alongside helices of an adjacent region. Two specific long-range interactions clamp the two halves of the domain together: a two-Mg2+-coordinated adenosine-rich corkscrew plugs into the minor groove of a helix, and a GAAA hairpin loop binds to a conserved 11-nucleotide internal loop. Metal- and ribose-mediated backbone contacts further stabilize the close side-by-side helical packing. The structure indicates the extent of RNA packing required for the function of large ribozymes, the spliceosome, and the ribosome. | |||
Crystal structure of a group I ribozyme domain: principles of RNA packing.,Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA Science. 1996 Sep 20;273(5282):1678-85. PMID:8781224<ref>PMID:8781224</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1gid" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Ribozyme 3D structures|Ribozyme 3D structures]] | *[[Ribozyme 3D structures|Ribozyme 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
