1yjd: Difference between revisions
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'''Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1)''' | '''Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1)''' | ||
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[[Category: Sorensen, P.]] | [[Category: Sorensen, P.]] | ||
[[Category: Stuart, D I.]] | [[Category: Stuart, D I.]] | ||
[[Category: | [[Category: Cd28 homodimer]] | ||
[[Category: | [[Category: Igsf]] | ||
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Revision as of 13:23, 3 May 2008
Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1)
Overview
Naive T cell activation requires signaling by the T cell receptor and by nonclonotypic cell surface receptors. The most important costimulatory protein is the monovalent homodimer CD28, which interacts with CD80 and CD86 expressed on antigen-presenting cells. Here we present the crystal structure of a soluble form of CD28 in complex with the Fab fragment of a mitogenic antibody. Structural comparisons redefine the evolutionary relationships of CD28-related proteins, antigen receptors and adhesion molecules and account for the distinct ligand-binding and stoichiometric properties of CD28 and the related, inhibitory homodimer CTLA-4. Cryo-electron microscopy-based comparisons of complexes of CD28 with mitogenic and nonmitogenic antibodies place new constraints on models of antibody-induced receptor triggering. This work completes the initial structural characterization of the CD28-CTLA-4-CD80-CD86 signaling system.
About this Structure
1YJD is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a soluble CD28-Fab complex., Evans EJ, Esnouf RM, Manso-Sancho R, Gilbert RJ, James JR, Yu C, Fennelly JA, Vowles C, Hanke T, Walse B, Hunig T, Sorensen P, Stuart DI, Davis SJ, Nat Immunol. 2005 Mar;6(3):271-9. Epub 2005 Feb 6. PMID:15696168 Page seeded by OCA on Sat May 3 16:23:41 2008
