1in0

YAJQ PROTEIN (HI1034)

spinqualitylabelsall models 1in0, resolution 2.14Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1in0 is a 2 chain structure with sequence from Haemophilus influenzae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.14Å Ligands: HG, MMC, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Y1034_HAEIN Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed A hypothetical protein encoded by the gene YajQ of Haemophilus influenzae was selected, as part of a structural genomics project, for X-ray crystallographic structure determination and analysis to assist with the functional assignment. The protein is present in most bacteria, but not in archaea or eukaryotes. The amino acid sequence has no homology to that of other proteins. The YajQ protein was cloned, expressed, and the crystal structure determined at 2.1-A resolution by applying the multiwavelength anomalous dispersion method to a mercury derivative. The polypeptide chain is folded into two domains with identical folding topology. Each domain has a four-stranded antiparallel beta-sheet flanked on one side by two alpha-helices. This structural motif is a characteristic feature of many RNA-binding proteins. The tetrameric structure observed in the crystal suggests a possibility of binding two stretches of double-stranded nucleic acid. Crystal structure of the YajQ protein from Haemophilus influenzae reveals a tandem of RNP-like domains.,Teplyakov A, Obmolova G, Bir N, Reddy P, Howard AJ, Gilliland GL J Struct Funct Genomics. 2003;4(1):1-9. PMID:12943362 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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