3psa: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/MOLA_HAEIN MOLA_HAEIN] Part of the ABC transporter complex MolBCA involved in molybdate import (PubMed:22078568, PubMed:24722984). Functions as a low-affinity molybdate transporter (PubMed:24722984). Binds to both molybdate and tungstate, but not to sulfate or phosphate (PubMed:22078568).<ref>PMID:22078568</ref> <ref>PMID:24722984</ref> | [https://www.uniprot.org/uniprot/MOLA_HAEIN MOLA_HAEIN] Part of the ABC transporter complex MolBCA involved in molybdate import (PubMed:22078568, PubMed:24722984). Functions as a low-affinity molybdate transporter (PubMed:24722984). Binds to both molybdate and tungstate, but not to sulfate or phosphate (PubMed:22078568).<ref>PMID:22078568</ref> <ref>PMID:24722984</ref> | ||
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== Publication Abstract from PubMed == | |||
molA (HI1472) from H. influenzae encodes a periplasmic binding protein (PBP) that delivers substrate to the ABC transporter MolB(2)C(2) (formerly HI1470/71). The structures of MolA with molybdate and tungstate in the binding pocket were solved to 1.6 and 1.7 A resolution, respectively. The MolA-binding protein binds molybdate and tungstate, but not other oxyanions such as sulfate and phosphate, making it the first class III molybdate-binding protein structurally solved. The approximately 100 muM binding affinity for tungstate and molybdate is significantly lower than observed for the class II ModA molybdate-binding proteins that have nanomolar to low micromolar affinity for molybdate. The presence of two molybdate loci in H. influenzae suggests multiple transport systems for one substrate, with molABC constituting a low-affinity molybdate locus. | |||
Classification of a Haemophilus influenzae ABC Transporter HI1470/71 through Its Cognate Molybdate Periplasmic Binding Protein, MolA.,Tirado-Lee L, Lee A, Rees DC, Pinkett HW Structure. 2011 Nov 9;19(11):1701-10. PMID:22078568<ref>PMID:22078568</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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== References == | == References == | ||
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