6cip: Difference between revisions
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<table><tr><td colspan='2'>[[6cip]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica_ATCC_39073 Moorella thermoacetica ATCC 39073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CIP FirstGlance]. <br> | <table><tr><td colspan='2'>[[6cip]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica_ATCC_39073 Moorella thermoacetica ATCC 39073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CIP FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.189Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.189Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HTL:2-ACETYL-THIAMINE+DIPHOSPHATE'>HTL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HTL:2-ACETYL-THIAMINE+DIPHOSPHATE'>HTL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cip OCA], [https://pdbe.org/6cip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cip RCSB], [https://www.ebi.ac.uk/pdbsum/6cip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cip ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cip OCA], [https://pdbe.org/6cip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cip RCSB], [https://www.ebi.ac.uk/pdbsum/6cip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cip ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PFOR_MOOTA PFOR_MOOTA] Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions (PubMed:10878009). The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood-Ljungdahl pathway of reductive acetogenesis. The conversion of acetyl-CoA to pyruvate links the Wood-Ljungdahl pathway of autotrophic CO2 fixation to the reductive tricarboxylic acid cycle (PubMed:10878009, PubMed:29581263). Can use methyl viologen as electron carrier in vitro (PubMed: | [https://www.uniprot.org/uniprot/PFOR_MOOTA PFOR_MOOTA] Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions (PubMed:10878009). The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood-Ljungdahl pathway of reductive acetogenesis. The conversion of acetyl-CoA to pyruvate links the Wood-Ljungdahl pathway of autotrophic CO2 fixation to the reductive tricarboxylic acid cycle (PubMed:10878009, PubMed:29581263). Can use methyl viologen as electron carrier in vitro (PubMed:29581263, PubMed:9214293).<ref>PMID:10878009</ref> <ref>PMID:29581263</ref> <ref>PMID:9214293</ref> <ref>PMID:10878009</ref> <ref>PMID:29581263</ref> | ||
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
