7rds: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 3: Line 3:
<StructureSection load='7rds' size='340' side='right'caption='[[7rds]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='7rds' size='340' side='right'caption='[[7rds]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7rds]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RDS FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RDS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rds OCA], [https://pdbe.org/7rds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rds RCSB], [https://www.ebi.ac.uk/pdbsum/7rds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rds ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rds OCA], [https://pdbe.org/7rds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rds RCSB], [https://www.ebi.ac.uk/pdbsum/7rds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rds ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NTH_HUMAN NTH_HUMAN] NTHL1-related attenuated familial adenomatous polyposis. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NTH_HUMAN NTH_HUMAN] Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage (PubMed:9927729). The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.[HAMAP-Rule:MF_03183]<ref>PMID:10882850</ref> <ref>PMID:11328882</ref> <ref>PMID:11380260</ref> <ref>PMID:11695910</ref> <ref>PMID:12140329</ref> <ref>PMID:12144783</ref> <ref>PMID:12519758</ref> <ref>PMID:14734554</ref> <ref>PMID:15533839</ref> <ref>PMID:17923696</ref> <ref>PMID:20005182</ref> <ref>PMID:20110254</ref> <ref>PMID:21930793</ref> <ref>PMID:8990169</ref> <ref>PMID:9045706</ref> <ref>PMID:9705289</ref> <ref>PMID:9890904</ref> <ref>PMID:9927729</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 25: Line 21:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Carroll BL]]
[[Category: Carroll BL]]
[[Category: Doublie S]]
[[Category: Doublie S]]
[[Category: Zahn KE]]
[[Category: Zahn KE]]
Retrieved from "https://proteopedia.org/7rds"