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==Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state==
==Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state==
<StructureSection load='8foh' size='340' side='right'caption='[[8foh]], [[Resolution|resolution]] 4.93&Aring;' scene=''>
<StructureSection load='8foh' size='340' side='right'caption='[[8foh]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[8foh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FOH FirstGlance]. <br>
<table><tr><td colspan='2'>[[8foh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FOH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.93&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8foh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8foh OCA], [https://pdbe.org/8foh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8foh RCSB], [https://www.ebi.ac.uk/pdbsum/8foh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8foh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8foh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8foh OCA], [https://pdbe.org/8foh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8foh RCSB], [https://www.ebi.ac.uk/pdbsum/8foh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8foh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/A0A8H4BVQ7_YEASX A0A8H4BVQ7_YEASX]  
[https://www.uniprot.org/uniprot/DPOLA_YEAST DPOLA_YEAST] Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase (PubMed:10898792, PubMed:22119860, PubMed:31488849). POL1 has a role in promoting telomere replication during interaction with CDC13 (PubMed:10898792).<ref>PMID:10898792</ref> <ref>PMID:22119860</ref> <ref>PMID:31488849</ref>


==See Also==
==See Also==
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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