9ijx: Difference between revisions
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==Crystal structure of the mouse Spef1 coiled-coil domain== | |||
<StructureSection load='9ijx' size='340' side='right'caption='[[9ijx]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ijx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IJX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ijx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ijx OCA], [https://pdbe.org/9ijx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ijx RCSB], [https://www.ebi.ac.uk/pdbsum/9ijx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ijx ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Li | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/SPEF1_MOUSE SPEF1_MOUSE] Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (PubMed:16206169). Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (PubMed:30535028). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (By similarity). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity).[UniProtKB:Q0IH24]<ref>PMID:16206169</ref> <ref>PMID:30535028</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Feng W]] | |||
[[Category: Li D]] | |||
[[Category: Ren J]] | |||
Latest revision as of 16:11, 13 August 2026
Crystal structure of the mouse Spef1 coiled-coil domain
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