26kb: Difference between revisions
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==Cryo-EM structure of Crimean-Congo hemorrhagic fever virus RNA polymerase in the apo3 state from the 5'/3' vRNA dual-promoter dataset== | |||
<StructureSection load='26kb' size='340' side='right'caption='[[26kb]], [[Resolution|resolution]] 2.76Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[26kb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthonairovirus_haemorrhagiae Orthonairovirus haemorrhagiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=26KB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=26KB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.76Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=26kb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=26kb OCA], [https://pdbe.org/26kb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=26kb RCSB], [https://www.ebi.ac.uk/pdbsum/26kb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=26kb ProSAT]</span></td></tr> | ||
[[Category: Liu | </table> | ||
[[Category: | == Function == | ||
[[Category: Wu | [https://www.uniprot.org/uniprot/L_CCHFI L_CCHFI] Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity. | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Orthonairovirus haemorrhagiae]] | |||
[[Category: Liang Z]] | |||
[[Category: Liu X]] | |||
[[Category: Ma J]] | |||
[[Category: Wu H]] | |||
[[Category: Yang K]] | |||
Latest revision as of 04:55, 19 August 2026
Cryo-EM structure of Crimean-Congo hemorrhagic fever virus RNA polymerase in the apo3 state from the 5'/3' vRNA dual-promoter dataset
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