9i85: Difference between revisions
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==Structure of Mcl-1 complex with small molecule inhibitor== | |||
<StructureSection load='9i85' size='340' side='right'caption='[[9i85]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9i85]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I85 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=A1I07:(2~{R})-2-[5-[3-chloranyl-2-methyl-5-[(4-methylpiperazin-1-yl)methyl]-4-oxidanyl-phenyl]-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic+acid'>A1I07</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i85 OCA], [https://pdbe.org/9i85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i85 RCSB], [https://www.ebi.ac.uk/pdbsum/9i85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i85 ProSAT]</span></td></tr> | ||
[[Category: Murray | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Dokurno P]] | |||
[[Category: Murray JB]] | |||
[[Category: Rubbard RE]] | |||
Latest revision as of 04:59, 19 August 2026
Structure of Mcl-1 complex with small molecule inhibitor
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