9tlu: Difference between revisions
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==De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-3 in complex with BCL-xL== | |||
<StructureSection load='9tlu' size='340' side='right'caption='[[9tlu]], [[Resolution|resolution]] 2.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9tlu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9TLU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99Å</td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tlu OCA], [https://pdbe.org/9tlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tlu RCSB], [https://www.ebi.ac.uk/pdbsum/9tlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tlu ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[[ | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: Acevedo-Jake | __TOC__ | ||
[[Category: Caulton | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Acevedo-Jake A]] | |||
[[Category: Caulton SG]] | |||
[[Category: Edwards TA]] | |||
[[Category: Lovering AL]] | |||
[[Category: Mylemans B]] | |||
[[Category: WIlson AJ]] | |||
[[Category: Woolfson DN]] | |||
Latest revision as of 05:05, 19 August 2026
De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-3 in complex with BCL-xL
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