9v0c: Difference between revisions

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~~'''Unreleased structure'''~~

The entry ~~9v0c~~ is ~~ON HOLD~~

==Cryo-EM structure of iberdomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9v0c]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V0C OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9V0C FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.27Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8W7:(3S)-3-[4-({4-[(MORPHOLIN-4-YL)METHYL]PHENYL}METHOXY)-1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL]PIPERIDINE-2,6-DIONE'>8W7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9v0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v0c OCA], [https://pdbe.org/9v0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v0c RCSB], [https://www.ebi.ac.uk/pdbsum/9v0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v0c ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Autosomal recessive nonsyndromic intellectual deficit;Distal monosomy 3p. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.<ref>PMID:18414909</ref> <ref>PMID:20223979</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Ai HS]]

[[Category: Deng ZH]]

[[Category: Liu L]]

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-'''Unreleased structure'''
-The entry 9v0c is ON HOLD
+==Cryo-EM structure of iberdomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly==
+<StructureSection load='9v0c' size='340' side='right'caption='[[9v0c]], [[Resolution|resolution]] 3.27&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9v0c]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V0C FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.27&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8W7:(3S)-3-[4-({4-[(MORPHOLIN-4-YL)METHYL]PHENYL}METHOXY)-1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL]PIPERIDINE-2,6-DIONE'>8W7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v0c OCA], [https://pdbe.org/9v0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v0c RCSB], [https://www.ebi.ac.uk/pdbsum/9v0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v0c ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Autosomal recessive nonsyndromic intellectual deficit;Distal monosomy 3p. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.<ref>PMID:18414909</ref> <ref>PMID:20223979</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Ai HS]]
+[[Category: Deng ZH]]
+[[Category: Liu L]]