9wbv: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9wbv is ~~ON HOLD~~

==Cryo-EM structure of the human UBR2 N-domain in complex with tryptophan==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9wbv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WBV OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9WBV FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.13Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9wbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wbv OCA], [https://pdbe.org/9wbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wbv RCSB], [https://www.ebi.ac.uk/pdbsum/9wbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wbv ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/UBR2_HUMAN UBR2_HUMAN] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.<ref>PMID:15548684</ref> <ref>PMID:20298436</ref> <ref>PMID:20835242</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Hu Z]]

[[Category: Yan R]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9wbv is ON HOLD
+==Cryo-EM structure of the human UBR2 N-domain in complex with tryptophan==
+<StructureSection load='9wbv' size='340' side='right'caption='[[9wbv]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9wbv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WBV FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wbv OCA], [https://pdbe.org/9wbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wbv RCSB], [https://www.ebi.ac.uk/pdbsum/9wbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wbv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UBR2_HUMAN UBR2_HUMAN] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.<ref>PMID:15548684</ref> <ref>PMID:20298436</ref> <ref>PMID:20835242</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Hu Z]]
+[[Category: Yan R]]