9zir: Difference between revisions
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==Crystal structure of sigma-2 receptor with zervimesine (CT1812)== | |||
<StructureSection load='9zir' size='340' side='right'caption='[[9zir]], [[Resolution|resolution]] 2.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9zir]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZIR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C2J:4-[3-methyl-3-(5-methylsulfonyl-1,3-dihydroisoindol-2-yl)butyl]-2-[(2-methylpropan-2-yl)oxy]phenol'>A1C2J</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zir OCA], [https://pdbe.org/9zir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zir RCSB], [https://www.ebi.ac.uk/pdbsum/9zir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zir ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SGMR2_BOVIN SGMR2_BOVIN] Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.<ref>PMID:28559337</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | |||
[[Category: Amaudrut J]] | |||
[[Category: Caggiano AO]] | |||
[[Category: Gilzer D]] | |||
[[Category: Hamby ME]] | |||
[[Category: Look GC]] | |||
[[Category: Malancona S]] | |||
[[Category: Montalbetti CAGN]] | |||
[[Category: Nitsche J]] | |||
[[Category: Preuss F]] | |||
[[Category: Wollenhaupt J]] | |||
Latest revision as of 05:09, 19 August 2026
Crystal structure of sigma-2 receptor with zervimesine (CT1812)
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