Proto-oncogene serine/threonine-protein kinase: Difference between revisions

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== Function ==
== Function ==
'''Proto-oncogene serine/threonine-protein kinase (Pim1)''' is the provirus integration site for Moloney murine leukemia virus 1<ref>PMID:15694833</ref>.  Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signaling pathways.  Pim1 phosphorylates and inhibits proapoptotic proteins.    For details see [[Student Project 6 for UMass Chemistry 423 Spring 2015]]. See also [[Oncogenes & Tumor Suppressor Genes]].
'''Proto-oncogene serine/threonine-protein kinase''' are a subset of '''serine/threonine-protein kinase''' which upon mutating cause cancer development.
*'''Chk1 or checkpoint kinase 1''' phosphorylates variety of proteins resulting in activation of DNA damage checkpoint and more<ref>PMID:23508805</ref>.
'''Proto-oncogene serine/threonine-protein kinase (Pim1)''' is the provirus integration site for Moloney murine leukemia virus 1<ref>PMID:15694833</ref>.  Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signalling pathways.  Pim1 phosphorylates and inhibits proapoptotic proteins.    For details see [[Student Project 6 for UMass Chemistry 423 Spring 2015]]. See also [[Oncogenes & Tumor Suppressor Genes]].
*'''Chk2 or checkpoint kinase 2''' has a role in cell cycle arrest and apoptosis by  DNA damage <ref>PMID:15279791</ref>.
*'''C-RAF''' regulates cell proliferation, cell death and metabolism<ref>PMID:29499332</ref>.
*'''Plk1 or Polo-like kinase 1''' phosphorylates variety of proteins affecting cell entry into mitosis, centrosome maturation, spindle assembly and cytokinesis<ref>PMID:34454931</ref>.
*'''B-RAF''' is mutated in ca. 7% of human cancers <ref>PMID:15279791</ref>.
*'''Plk3 or Polo-like kinase 3''' becomes phosphorylated after DNA damage or mitotic spindle disruption <ref>PMID:12242661</ref>.
*'''A-RAF''' stabilizes B-RAF:C-RAF complexes and thus regulates cell signalling<ref>PMID:22926515</ref>.
*'''Haspin''' phosphorylates histone H3 and thus affects mitosis <ref>PMID:28413956</ref>.
*'''AKT1''' has a role in tumor progression<ref>PMID:38860522</ref>.
*'''mTOR or mechanistic target of rapamycin''' signaling influences longevity and aging <ref>PMID:29190625</ref>.
*'''AKT2''' is critical to control of glucose metabolism by insulin <ref>PMID:19883618</ref>.
*'''AKT3''' is required for biogenesis of mitochondria <ref>PMID:24081905</ref>.
*'''LRRK1, LRRK2 or leucine-rich repeat kinase''' phosphorylate Rab proteins  <ref>PMID:33459343</ref>.
*'''LRRK1, LRRK2 or leucine-rich repeat kinase''' phosphorylate Rab proteins  <ref>PMID:33459343</ref>.
*'''RIP''' regulates apoptosis<ref>PMID:9529147</ref>.
*'''RIP''' regulates apoptosis<ref>PMID:9529147</ref>.

Revision as of 09:28, 24 August 2026

Pim-1 complex with consensus peptide, inhibitor and Cl- ion 3cy2

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References

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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