Proto-oncogene serine/threonine-protein kinase: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
Michal Harel (talk | contribs)
32,805 edits
No edit summary
Michal Harel (talk | contribs)
32,805 edits
No edit summary
Line 4: Line 4:
'''Proto-oncogene serine/threonine-protein kinase''' are a subset of '''serine/threonine-protein kinase''' which upon mutating cause cancer development.
'''Proto-oncogene serine/threonine-protein kinase''' are a subset of '''serine/threonine-protein kinase''' which upon mutating cause cancer development.
'''Proto-oncogene serine/threonine-protein kinase (Pim1)''' is the provirus integration site for Moloney murine leukemia virus 1<ref>PMID:15694833</ref>.  Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signalling pathways.  Pim1 phosphorylates and inhibits proapoptotic proteins.    For details see [[Student Project 6 for UMass Chemistry 423 Spring 2015]]. See also [[Oncogenes & Tumor Suppressor Genes]].
'''Proto-oncogene serine/threonine-protein kinase (Pim1)''' is the provirus integration site for Moloney murine leukemia virus 1<ref>PMID:15694833</ref>.  Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signalling pathways.  Pim1 phosphorylates and inhibits proapoptotic proteins.    For details see [[Student Project 6 for UMass Chemistry 423 Spring 2015]]. See also [[Oncogenes & Tumor Suppressor Genes]].
*'''C-RAF''' regulates cell proliferation, cell death and metabolism<ref>PMID:29499332</ref>.
* '''b-Raf''' is related to retroviral oncogenes and participates in cellular signal transduction. B-Raf domains include the kinase domain - residues 444-721 and Ras-binding domain - residues 153-237.  Mutated B-Raf was found in some human cancers<ref>PMID:12460918</ref>.  
*'''B-RAF''' is mutated in ca. 7% of human cancers <ref>PMID:15279791</ref>.
See more in [[B-RAF with PLX4032]]; [[Mitogen-activated protein kinase cascade]].
*'''A-RAF''' stabilizes B-RAF:C-RAF complexes and thus regulates cell signalling<ref>PMID:22926515</ref>.
 
* '''c-Raf''' is part of the MAPK pathway.  c-Raf domains include the kinase domain - residues 323-618, cysteine-rich domain – residues 136-187 and Ras-binding domain - residues 51-132. Mutations of c-Raf are possible causes of Noonan syndrome<ref>PMID:23737487</ref>.  For details on '''c-Raf''' see [[Molecular Playground/C-Raf]] and [[Mitogen-activated protein kinase cascade]].
*'''a-RAF''' stabilizes B-RAF:C-RAF complexes and thus regulates cell signalling<ref>PMID:22926515</ref>.
*'''AKT1'''  has a role in tumor progression<ref>PMID:38860522</ref>.
*'''AKT1'''  has a role in tumor progression<ref>PMID:38860522</ref>.
*'''AKT2''' is critical to control of glucose metabolism by insulin <ref>PMID:19883618</ref>.
*'''AKT2''' is critical to control of glucose metabolism by insulin <ref>PMID:19883618</ref>.

Revision as of 09:46, 24 August 2026

Pim-1 complex with consensus peptide, inhibitor and Cl- ion 3cy2

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "https://proteopedia.org/index.php?title=Proto-oncogene_serine/threonine-protein_kinase&oldid=4482888"