9t5m: Difference between revisions

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'''Unreleased structure'''


The entry 9t5m is ON HOLD
==Structure of mouse full-length LRRC8D==
 
<StructureSection load='9t5m' size='340' side='right'caption='[[9t5m]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
Authors: Lehmann, E.F., Deneka, D., Stierli, F., Rutz, S., Dutzler, R.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9t5m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T5M FirstGlance]. <br>
Description: Structure of mouse full-length LRRC8D
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t5m OCA], [https://pdbe.org/9t5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t5m RCSB], [https://www.ebi.ac.uk/pdbsum/9t5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t5m ProSAT]</span></td></tr>
[[Category: Rutz, S]]
</table>
[[Category: Lehmann, E.F]]
== Function ==
[[Category: Dutzler, R]]
[https://www.uniprot.org/uniprot/LRC8D_MOUSE LRC8D_MOUSE] Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29773801, PubMed:36522427). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29773801). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:36522427).[UniProtKB:Q7L1W4]<ref>PMID:29773801</ref> <ref>PMID:36522427</ref>
[[Category: Stierli, F]]
== References ==
[[Category: Deneka, D]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Deneka D]]
[[Category: Dutzler R]]
[[Category: Lehmann EF]]
[[Category: Rutz S]]
[[Category: Stierli F]]
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