9t5r: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9t5r is ~~ON HOLD until Paper Publication~~

==LRR domain structure of the LRRC8D protein==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9t5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T5R OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9T5R FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9t5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t5r OCA], [https://pdbe.org/9t5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t5r RCSB], [https://www.ebi.ac.uk/pdbsum/9t5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t5r ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/LRC8D_MOUSE LRC8D_MOUSE] Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29773801, PubMed:36522427). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29773801). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:36522427).[UniProtKB:Q7L1W4]<ref>PMID:29773801</ref> <ref>PMID:36522427</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Deneka D]]

[[Category: Dutzler R]]

[[Category: Lehmann EF]]

[[Category: Rutz S]]

[[Category: Stierli F]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9t5r is ON HOLD  until Paper Publication
+==LRR domain structure of the LRRC8D protein==
+<StructureSection load='9t5r' size='340' side='right'caption='[[9t5r]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9t5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T5R FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t5r OCA], [https://pdbe.org/9t5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t5r RCSB], [https://www.ebi.ac.uk/pdbsum/9t5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t5r ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LRC8D_MOUSE LRC8D_MOUSE] Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29773801, PubMed:36522427). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29773801). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:36522427).[UniProtKB:Q7L1W4]<ref>PMID:29773801</ref> <ref>PMID:36522427</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Deneka D]]
+[[Category: Dutzler R]]
+[[Category: Lehmann EF]]
+[[Category: Rutz S]]
+[[Category: Stierli F]]