9yc4: Difference between revisions
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==Covalent stabilizer of the interaction between 14-3-3 sigma and Estrogen receptor-alpha peptide== | |||
<StructureSection load='9yc4' size='340' side='right'caption='[[9yc4]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9yc4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YC4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.152Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CT3:(2R)-1-[(3R,5S)-4-(chloroacetyl)-3,5-dimethylpiperazin-1-yl]-2-(4-chlorophenyl)-2-[1-(1-methyl-1H-pyrazole-4-carbonyl)piperidin-4-yl]ethan-1-one'>A1CT3</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
[[Category: Knapp | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yc4 OCA], [https://pdbe.org/9yc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yc4 RCSB], [https://www.ebi.ac.uk/pdbsum/9yc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yc4 ProSAT]</span></td></tr> | ||
[[Category: Tang | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Knapp MS]] | |||
[[Category: Tang JY]] | |||
Latest revision as of 16:55, 8 September 2026
Covalent stabilizer of the interaction between 14-3-3 sigma and Estrogen receptor-alpha peptide
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