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'''Unreleased structure'''


The entry 9q8m is ON HOLD  until Paper Publication
==VPS35-VPS26-SNX12 Complex==
 
<StructureSection load='9q8m' size='340' side='right'caption='[[9q8m]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
Authors: Pardo, M., Rojas, A.L., Hierro, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9q8m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Q8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Q8M FirstGlance]. <br>
Description: VPS35-VPS26-SNX12 Complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Pardo, M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9q8m OCA], [https://pdbe.org/9q8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9q8m RCSB], [https://www.ebi.ac.uk/pdbsum/9q8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9q8m ProSAT]</span></td></tr>
[[Category: Hierro, A]]
</table>
[[Category: Rojas, A.L]]
== Disease ==
[https://www.uniprot.org/uniprot/VPS35_HUMAN VPS35_HUMAN] Defects in VPS35 are the cause of Parkinson disease type 17 (PARK17) [MIM:[https://omim.org/entry/614203 614203]. PARK17 is an autosomal dominant, adult-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.<ref>PMID:21763482</ref> <ref>PMID:21763483</ref> <ref>PMID:22517097</ref>
== Function ==
[https://www.uniprot.org/uniprot/VPS35_HUMAN VPS35_HUMAN] Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).<ref>PMID:15247922</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human papillomavirus type 16]]
[[Category: Large Structures]]
[[Category: Hierro A]]
[[Category: Pardo M]]
[[Category: Rojas AL]]
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