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'''Solution structure of the central region of the human GluR-B R/G pre-mRNA''' | '''Solution structure of the central region of the human GluR-B R/G pre-mRNA''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA]. | |||
==Reference== | ==Reference== | ||
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15840813 15840813] | A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15840813 15840813] | ||
[[Category: Allain, F H.]] | [[Category: Allain, F H.]] | ||
[[Category: Stefl, R.]] | [[Category: Stefl, R.]] | ||
[[Category: | [[Category: Adar2]] | ||
[[Category: | [[Category: Nmr]] | ||
[[Category: | [[Category: Pentaloop]] | ||
[[Category: | [[Category: Rna]] | ||
[[Category: | [[Category: Rna editing]] | ||
[[Category: | [[Category: Stem-loop]] | ||
[[Category: | [[Category: Structure]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:44:38 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 13:44, 3 May 2008
Solution structure of the central region of the human GluR-B R/G pre-mRNA
Overview
Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.
About this Structure
Full crystallographic information is available from OCA.
Reference
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:15840813 Page seeded by OCA on Sat May 3 16:44:38 2008
