37on: Difference between revisions
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==Crystal structure of the Mucin-type O-glycosyltransferase PGANT5A-4M (A430T, L434N, A437N, S456Y)== | |||
<StructureSection load='37on' size='340' side='right'caption='[[37on]], [[Resolution|resolution]] 3.08Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[37on]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=37ON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=37ON FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.08Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> | ||
[[Category: Kumar | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=37on FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=37on OCA], [https://pdbe.org/37on PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=37on RCSB], [https://www.ebi.ac.uk/pdbsum/37on PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=37on ProSAT]</span></td></tr> | ||
[[Category: Samara | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GALT5_DROME GALT5_DROME] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12829714, PubMed:18669915). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers EA2 as substrate (PubMed:12829714). In the larval midgut, required for O-glycosylation of apical and luminal proteins within copper cells enabling proper gut acidification (PubMed:22157008).<ref>PMID:12829714</ref> <ref>PMID:18669915</ref> <ref>PMID:22157008</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Drosophila melanogaster]] | |||
[[Category: Large Structures]] | |||
[[Category: Kumar P]] | |||
[[Category: Samara NL]] | |||
Latest revision as of 08:27, 16 September 2026
Crystal structure of the Mucin-type O-glycosyltransferase PGANT5A-4M (A430T, L434N, A437N, S456Y)
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