9r8m: Difference between revisions
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The entry | ==Structure of human NHE6.1 bound to PIP2== | ||
<StructureSection load='9r8m' size='340' side='right'caption='[[9r8m]], [[Resolution|resolution]] 2.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9r8m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9R8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9R8M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.55Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JDN:[(2~{R})-2-hexadecanoyloxy-3-[oxidanyl-[(2~{R},3~{S},5~{R},6~{R})-2,4,6-tris(oxidanyl)-3,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl]+hexadecanoate'>A1JDN</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=PCF:1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE'>PCF</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9r8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9r8m OCA], [https://pdbe.org/9r8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9r8m RCSB], [https://www.ebi.ac.uk/pdbsum/9r8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9r8m ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/SL9A6_HUMAN SL9A6_HUMAN] Christianson syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease may be caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SL9A6_HUMAN SL9A6_HUMAN] Endosomal Na(+), K(+)/H(+) antiporter (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (PubMed:20130086). Regulates intracellular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity).[UniProtKB:A1L3P4]<ref>PMID:15522866</ref> <ref>PMID:20130086</ref> <ref>PMID:28635961</ref> <ref>PMID:31676550</ref> <ref>PMID:32277048</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Beck H]] | |||
[[Category: Chi G]] | |||
[[Category: Goericke F]] | |||
[[Category: Hansen JS]] | |||
[[Category: Huber KVM]] | |||
[[Category: Ingles-Prieto A]] | |||
[[Category: Pike ACW]] | |||
[[Category: Sauer DB]] | |||
[[Category: Speedman D]] | |||
[[Category: Superti-Furga G]] | |||
[[Category: Tranberg-Jensen J]] | |||
[[Category: Wolf G]] | |||
[[Category: Ye M]] | |||
Latest revision as of 08:34, 16 September 2026
Structure of human NHE6.1 bound to PIP2
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