9zkd: Difference between revisions

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'''Unreleased structure'''


The entry 9zkd is ON HOLD  until Paper Publication
==Structure of RY12 domain of rabbit RyR1 complexed with ADP and Mg2+ (mimicking muscle fatigue)==
 
<StructureSection load='9zkd' size='340' side='right'caption='[[9zkd]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
Authors: Kim, K., Clarke, O.B.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9zkd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZKD FirstGlance]. <br>
Description: Structure of RY12 domain of rabbit RyR1 complexed with ADP and Mg2+ (mimicking muscle fatigue)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Kim, K]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zkd OCA], [https://pdbe.org/9zkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zkd RCSB], [https://www.ebi.ac.uk/pdbsum/9zkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zkd ProSAT]</span></td></tr>
[[Category: Clarke, O.B]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Clarke OB]]
[[Category: Kim K]]
Retrieved from "https://proteopedia.org/9zkd"